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Recent Citations

Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody. Rappazzo CG, Tse LV et al. Science. 2021 Feb 19;371(6531):823-829.

Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases. Li W, Tian W et al. Nature. 2021 Feb 18;590(7846):498-503.

Structure of a microtubule-bound axonemal dynein. Walton T, Wu H, Brown A. Nat Commun. 2021 Jan 20;12(1):477.

Immature HIV-1 assembles from Gag dimers leaving partial hexamers at lattice edges as potential substrates for proteolytic maturation. Tan A, Pak AJ et al. Proc Natl Acad Sci USA. 2021 Jan 19;118(3):e2020054118.

Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81. Susa KJ, Rawson S et al. Science. 2021 Jan 15;371(6526):300-305.

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News

December 18, 2020

Chimera production release 1.15 is now available. See the release notes for what's new.

December 11, 2020

The RBVI wishes you a safe and happy holiday season! See our 2020 card and the gallery of previous cards back to 1985.

November 4, 2020

A 1.15 production release candidate is available, including a fix to work with the new PDB fetch locations (see the release notes). Please try it and report any problems.

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Upcoming Events

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features. ChimeraX includes a significant subset of Chimera features (with more to come, see the missing features list) and is under active development. Users may choose to use both programs, and it is fine to have both installed.

Chimera is no longer under active development, and is only updated for critical maintenance. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

5 comparative models
Model List dialog

Chimera Interface to Modeller

Chimera provides a graphical interface to running the program Modeller, either locally or via a web service hosted by the UCSF RBVI. Two types of calculations are available:

  • Comparative (homology) modeling. Theoretical models of a protein target are generated using at least one known related template structure and a target-template sequence alignment. There are several ways to generate these inputs in Chimera. See also the Comparative Modeling tutorial.

  • Building parts of a protein without using a template. Missing segments can be built de novo, or existing segments refined by generating additional possible conformations.
Modeller is developed by the Sali Lab.

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Gallery Sample

Peroxiredoxin Wreath

Peroxiredoxins are enzymes that help cells cope with stressors such as high levels of reactive oxygen species. The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry 1qmv), styled as a holiday wreath.

See also the RBVI holiday card gallery.

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