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Recent Citations

Structural basis for the modulation of voltage-gated sodium channels by animal toxins. Shen H, Li Z et al. Science. 2018 Oct 19;362(6412). pii: eaau2596.

Structure and dynamics of the yeast SWR1-nucleosome complex. Willhoft O, Ghoneim M et al. Science. 2018 Oct 12;362(6411). pii: eaat7716.

A viral protein restricts Drosophila RNAi immunity by regulating Argonaute activity and stability. Nayak A, Kim DY et al. Cell Host Microbe. 2018 Oct 10;24(4):542-557.e9.

High-resolution structures of HIV-1 Gag cleavage mutants determine structural switch for virus maturation. Mattei S, Tan A et al. Proc Natl Acad Sci USA. 2018 Oct 2;115(40):E9401-E9410.

Structural basis for activation of voltage sensor domains in an ion channel TPC1. Kintzer AF, Green EM et al. Proc Natl Acad Sci USA. 2018 Sep 25;115(39):E9095-E9104.

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Chimera Search

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September 21, 2018

Mac users are advised to hold off upgrading to Mojave until we find a fix for Chimera buttons not being shown until the windows containing them are resized.

July 3, 2018

Chimera production release 1.13 is now available. See the release notes for what's new.

June 2, 2018

A production release candidate (version 1.13) is available; please try it and report any problems. See the release notes for what's new.

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Upcoming Events

UCSF Chimera is a highly extensible program for interactive visualization and analysis of molecular structures and related data, including density maps, supramolecular assemblies, sequence alignments, docking results, trajectories, and conformational ensembles. High-quality images and animations can be generated. Chimera includes complete documentation and several tutorials, and can be downloaded free of charge for academic, government, nonprofit, and personal use. Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics (RBVI), supported in part by the National Institutes of Health (P41-GM103311).

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the RBVI, following UCSF Chimera.

Feature Highlight

surface color by density

Coloring by Density

A surface can be colored by density or other volume data. In the image, the surface is clipped and capped, and only the cap is colored by density. Different coloring schemes can be applied.

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Gallery Sample

Cavity and Tunnel Detection

Side-by-side views of a potassium channel structure (Protein Data Bank entry 1bl8) showing different approaches to cavity detection. On the left are molecular surface patches corresponding to the structure's two largest pockets by MS volume in the Computed Atlas of Surface Topography of proteins (CASTp) database. On the right is a tunnel in blue identified by the MolAxis server. Simple editing converted MolAxis output into a BILD file for display in Chimera. (More samples...)

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