<html><head><meta http-equiv="content-type" content="text/html; charset=us-ascii"></head><body style="overflow-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;">Hi Roger,<div><br></div><div> Unifold looks interesting.</div><div><br></div><div><span class="Apple-tab-span" style="white-space:pre"> </span><a href="https://github.com/dptech-corp/Uni-Fold">https://github.com/dptech-corp/Uni-Fold</a></div><div><br></div><div>It is an open source reimplementation of AlphaFold using the PyTorch machine learning framework done by a China-based company called DPTech (<a href="https://www.dptech.com/">https://www.dptech.com/</a>). From reading the github page it sounds like one of its main advantages over AlphaFold is that the training code and protocol is all open source. Code for the training of AlphaFold was never made available as far as I know.</div><div><br></div><div> That is all nice, but what are the best reasons for our UCSF lab to try to offer this in ChimeraX? The ChimeraX AlphaFold user interface took about 2 months of development with ongoing maintenance. I'd estimate the cost so far at $30,000. ChimeraX is funded by NIH grants. Is it worth expending similar resources to implement and maintain an interface to UniFold?</div><div><br></div><div><span class="Apple-tab-span" style="white-space: pre;"> </span>Tom</div><div><br><div><br><blockquote type="cite"><div>On Apr 12, 2023, at 2:24 PM, Roger Leng via ChimeraX-users <chimerax-users@cgl.ucsf.edu> wrote:</div><br class="Apple-interchange-newline"><div><div dir="ltr"><div class="gmail_default" style="font-family:arial,helvetica,sans-serif">Dear Administrators,</div><div class="gmail_default" style="font-family:arial,helvetica,sans-serif"><br></div><div class="gmail_default" style="font-family:arial,helvetica,sans-serif">Is it possible to add "unifold" in your prediction, just like Alphafold?</div><div class="gmail_default" style="font-family:arial,helvetica,sans-serif"><br></div><div class="gmail_default" style="font-family:arial,helvetica,sans-serif">Thank you.</div><div class="gmail_default" style="font-family:arial,helvetica,sans-serif"><br></div><div class="gmail_default" style="font-family:arial,helvetica,sans-serif">Sincerely,</div><div class="gmail_default" style="font-family:arial,helvetica,sans-serif"><br></div><div class="gmail_default" style="font-family:arial,helvetica,sans-serif">Roger Leng</div></div>
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