GPCRDB has a list of structures at http://www.gpcr.org/7tm/updates?wicket:bookmarkablePage=:nl.ru.cmbi.mcsis.web.pages.proteinstructure.ProteinStructureOverviewPage --opsin/rhodopsin 1u19 1l9h 1hzx 1f88 2i35 3cap 2.90 Park, J.H., Scheerer, P., Hofmann, K.P., Choe, H.-W., Ernst, O.P. Crystal structure of the ligand-free G-protein-coupled receptor opsin Nature 454, 183 - 187 (18 Jun 2008) http://www.nature.com/nature/journal/v454/n7201/full/nature07063.html 4a4m constitutively active N2C, M257Y, D282C rhodopsin mutant Deupi X, Edwards P, Singhal A, Nickle B, Oprian D, Schertler G, Standfuss J. Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II. Proc Natl Acad Sci U S A. 2011 Dec 23;. [Epub ahead of print] 4zwj 3.30 Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser. Kang Y, Zhou XE, Gao X, He Y, Liu W, Ishchenko A, Barty A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Ke J, Tan MH, Zhang C, Moeller A, West GM, Pascal BD, Van Eps N, Caro LN, Vishnivetskiy SA, Lee RJ, Suino-Powell KM, Gu X, Pal K, Ma J, Zhi X, Boutet S, Williams GJ, Messerschmidt M, Gati C, Zatsepin NA, Wang D, James D, Basu S, Roy-Chowdhury S, Conrad CE, Coe J, Liu H, Lisova S, Kupitz C, Grotjohann I, Fromme R, Jiang Y, Tan M, Yang H, Li J, Wang M, Zheng Z, Li D, Howe N, Zhao Y, Standfuss J, Diederichs K, Dong Y, Potter CS, Carragher B, Caffrey M, Jiang H, Chapman HN, Spence JC, Fromme P, Weierstall U, Ernst OP, Katritch V, Gurevich VV, Griffin PR, Hubbell WL, Stevens RC, Cherezov V, Melcher K, Xu HE. Nature. 2015 Jul 22. doi: 10.1038/nature14656. [Epub ahead of print] PMID: 26200343 --beta1 adrenergic receptor 2vt4 2.70 cyanopindolol and stabilizing mutations Warne T, Serrano-Vega MJ, Baker JG, Moukhametzianov R, Edwards PC, Henderson R, Leslie AG, Tate CG, Schertler GF. Structure of a beta(1)-adrenergic G-protein-coupled receptor. Nature. 2008 454:486. http://www.nature.com/nature/journal/vaop/ncurrent/full/nature07101.html 4bvn 2.10 cyanopindolol and stabilizing mutations The 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor. Miller-Gallacher JL, Nehmé R, Warne T, Edwards PC, Schertler GF, Leslie AG, Tate CG. PLoS One. 2014 Mar 24;9(3):e92727. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0092727 2ycw 2ycx 2ycy 2ycz Moukhametzianov R, Warne T, Edwards PC, Serrano-Vega MJ, Leslie AG, Tate CG, Schertler GF. Two distinct conformations of helix 6 observed in antagonist-bound structures of a beta1-adrenergic receptor. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8228-32. http://www.pnas.org/content/108/20/8228.long --beta2 adrenergic receptor 2rh1 2.40 lysozyme fusion Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science. 2007 Nov 23;318(5854):1258-65. http://www.sciencemag.org/cgi/content/full/318/5854/1258 3d4s 2.80 lysozyme fusion, cholesterol 2r4r 3.40 Fab complex 2r4s 3.40 Fab complex 3ny8 3ny9 3nya 3pds 3.50 lysozyme fusion, cholesterol Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara RK, Chae PS, Gellman SH, Dror RO, Shaw DE, Weis WI, Caffrey M, Gmeiner P, Kobilka BK. Nature. 2011 Jan 13;469(7329):236-40. 3p0g 3.50 lysozyme fusion Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS, Schnapp A, Konetzki I, Sunahara RK, Gellman SH, Pautsch A, Steyaert J, Weis WI, Kobilka BK. Nature. 2011 Jan 13;469(7329):175-80 3sn6 Crystal structure of the β2 adrenergic receptor-Gs protein complex. Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK. Nature. 2011 Jul 19;477(7366):549-55. doi: 10.1038/nature10361. --adenosine receptor 3eml 2.60 lysozyme fusion Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EY, Lane JR, Ijzerman AP, Stevens RC. The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist. Science. 2008 Nov 21;322(5905):1211-7. http://www.sciencemag.org/cgi/content/abstract/1164772v1 3qak with conformationally selective agonist Structure of an Agonist-Bound Human A2A Adenosine Receptor. Xu F, Wu H, Katritch V, Han GW, Jacobson KA, Gao ZG, Cherezov V, Stevens RC. Science. 2011 Apr 15;332(6027):322-327. 2ydo adenosine complex 2ydv NECA complex Lebon G, Warne T, Edwards PC, Bennett K, Langmead CJ, Leslie AG, Tate CG. Agonist-bound adenosine A(2A) receptor structures reveal common features of GPCR activation. Nature. 2011 May 18;474(7352):521-5. doi: 10.1038/nature10136. 5g53 A2AR-mini-Gs complex Structure of the adenosine A2A receptor bound to an engineered G protein. Carpenter B, Nehmé R, Warne T, Leslie AG, Tate CG. Nature. 2016 Jul 27. doi: 10.1038/nature18966. [Epub ahead of print] --dopamine D3 receptor 3pbl lysozyme fusion Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Chien EY, Liu W, Zhao Q, Katritch V, Han GW, Hanson MA, Shi L, Newman AH, Javitch JA, Cherezov V, Stevens RC. Science. 2010 Nov 19;330(6007):1091-5. --delta opioid receptor 4ej4 3.40 naltrindole complex, lysozyme fusion Structure of the δ-opioid receptor bound to naltrindole. Granier S, Manglik A, Kruse AC, Kobilka TS, Thian FS, Weis WI, Kobilka BK. Nature. 2012 May 16;485(7398):400-4. doi: 10.1038/nature11111. 4n6h 1.80 cytb562 fusion, human delta-OR Molecular control of δ-opioid receptor signalling. Fenalti G, Giguere PM, Katritch V, Huang XP, Thompson AA, Cherezov V, Roth BL, Stevens RC. Nature. 2014 Feb 13;506(7487):191-6. doi: 10.1038/nature12944. --mu opioid receptor 4dkl 2.80 lysozyme fusion Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S. Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature. 2012 Mar 21;485(7398):321-6. doi: 10.1038/nature10954. 5c1m 2.10 mouse muOR complex with agonist BU72 and G-protein mimetic nanobody Structural insights into µ-opioid receptor activation. Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK. Nature. 2015 Aug 5. doi: 10.1038/nature14886. [Epub ahead of print] PMID: 26245379 --kappa opioid receptor 4djh 2.90 lysozyme fusion --CXCR4 chemokine receptor 3odu 3oe0 3oe6 3oe8 3oe9 Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V, Stevens RC. Science. 2010 Nov 19;330(6007):1066-71. 4rws Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Ling Qin, Irina Kufareva, Lauren G. Holden, Chong Wang, Yi Zheng, Chunxia Zhao, Gustavo Fenalti, Huixian Wu, Gye Won Han, Vadim Cherezov, Ruben Abagyan, Raymond C. Stevens, and Tracy M. Handel Science 6 March 2015: 1117-1122. --cannabinoid CB1 receptor 5tjv High-resolution crystal structure of the human CB1 cannabinoid receptor. Shao Z, Yin J, Chapman K, Grzemska M, Clark L, Wang J, Rosenbaum DM. Nature. 2016 Nov 16;. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/27851727 --viral chemokine receptor US28 4xt1 4xt3 Structural basis for chemokine recognition and activation of a viral G protein–coupled receptor. John S. Burg, Jessica R. Ingram, A. J. Venkatakrishnan, Kevin M. Jude, Abhiram Dukkipati, Evan N. Feinberg, Alessandro Angelini, Deepa Waghray, Ron O. Dror, Hidde L. Ploegh, and K. Christopher Garcia Science 6 March 2015: 1113-1117. --sphingosine 1-phosphate receptor 3v2w antagonist complex, lysozyme fusion 3v2y antagonist complex, lysozyme fusion Crystal Structure of a Lipid G Protein–Coupled Receptor. Hanson MA, Roth CB, et al. Science 17 February 2012: 851-855. --neurotensin receptor NTS1R rat 3zev 3.00 neurotensin complex 4buo 2.75 neurotensin complex 4bvo 3.10 4bwb 3.57 Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli. Egloff P, Hillenbrand M, Klenk C, Batyuk A, Heine P, Balada S, Schlinkmann KM, Scott DJ, Schütz M, Plückthun A. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E655-62. http://www.ncbi.nlm.nih.gov/pubmed/24453215 4grv 2.80 neurotensin (8-13) complex Structure of the agonist-bound neurotensin receptor. White JF, Noinaj N, Shibata Y, Love J, Kloss B, Xu F, Gvozdenovic-Jeremic J, Shah P, Shiloach J, Tate CG, Grisshammer R. Nature. 2012 Oct 25;490(7421):508-13. doi: 10.1038/nature11558. http://www.nature.com/nature/journal/v490/n7421/full/nature11558.html --orexin 2 receptor human 4s0v 2.50 glycogen synthase catalytic domain insertion, complex with antagonist Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant. Yin J, Mobarec JC, Kolb P, Rosenbaum DM. Nature. 2015 Mar 12;519(7542):247-50. doi: 10.1038/nature14035. http://www.nature.com/nature/journal/v519/n7542/full/nature14035.html --free fatty-acid receptor 1 human (FFAR1, hGPR40) 4phu 2.30 lysozyme insertion, complex with partial agonist High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875. Srivastava A, Yano J, Hirozane Y, Kefala G, Gruswitz F, Snell G, Lane W, Ivetac A, Aertgeerts K, Nguyen J, Jennings A, Okada K. Nature. 2014 Sep 4;513(7516):124-7. doi: 10.1038/nature13494. http://www.nature.com/nature/journal/v513/n7516/full/nature13494.html ------------------------------------------------------------------------------- CLASS B --CRFR human corticotropin-releasing factor receptor 1 4k5y 2.98 NTD removed, lysozyme insertion, complex with antagonist Structure of class B GPCR corticotropin-releasing factor receptor 1. Hollenstein K, Kean J, Bortolato A, Cheng RK, Doré AS, Jazayeri A, Cooke RM, Weir M, Marshall FH. Nature. 2013 Jul 25;499(7459):438-43. http://www.nature.com/nature/journal/v499/n7459/full/nature12357.html --hGCGR human glucagon receptor 4l6r 3.3 NTD replaced with cytb562 Structure of the human glucagon class B G-protein-coupled receptor. Siu FY, He M, de Graaf C, Han GW, Yang D, Zhang Z, Zhou C, Xu Q, Wacker D, Joseph JS, Liu W, Lau J, Cherezov V, Katritch V, Wang MW, Stevens RC. Nature. 2013 Jul 25;499(7459):444-9. http://www.nature.com/nature/journal/v499/n7459/full/nature12393.html ------------------------------------------------------------------------------- CLASS C --mGlu1R human metabotropic glutamate receptor 4or2 2.80 cytb562 chimera, complex with negative allosteric modulator Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator. Wu H et al. Science 4 April 2014: Vol. 344 no. 6179 pp. 58-64 http://www.sciencemag.org/content/344/6179/58.full -------------------------------------------------------------------------------