[Chimera-users] modeling selected protein mutations to a sequence

[David Sáez]

I am not an expert, but I think you can load a PDB file and select the
residue you want to mutate. Then Tools > Structure Editing > Rotamers.

A nice tutorial: https://www.youtube.com/watch?v=bcXMexN6hjY

Regards.

On Thu, Apr 2, 2020 at 5:37 PM Teresa Brito-Robinson <
Teresa.Brito-Robinson.2 at nd.edu> wrote:

> Hi Chimera users,
>
> I am trying chimera for the first time and my question is:
>
>
>    - How can I change (substitute) specific amino acids within an
>    uploaded protein sequence to mimic a missense mutation?
>
>
>
>    - Or how can I enter a whole new custom made protein sequence into
>    chimera, so I can probe different variants of a protein sequence.
>
> I don't know how to make the file like pdb (protein database) so I can
> fetch my custom sequence?
>
> Thanks!
>
> Teresa
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