[chimerax-users] ISOLDE 1.0b3 now released for ChimeraX 0.9

Tristan Croll tic20 at cam.ac.uk
Mon Jun 17 10:56:59 PDT 2019


Dear ChimeraX users,

Just letting you know that I've released ISOLDE 1.0b3 on the ChimeraX 
Tool Shed for use with ChimeraX 0.9. If you're not familiar with ISOLDE, 
you can get an overview at https://isolde.cimr.cam.ac.uk/. In brief, 
ISOLDE is designed to allow the high-fidelity, interactive 
remodelling/refinement of atomic models into low-medium resolution 
cryo-EM or crystallographic electron density maps.

In designing ISOLDE, I've always had two groups in mind. The first is, 
of course, the experimental structural biologists whose job it is to 
solve the structures of new macromolecules and their complexes. The 
second (and, to my mind, equally important) group is the downstream 
*users* of such models. Like every other human endeavour, macromolecular 
model building is an imperfect field, and (particularly in the 
worse-than-2-Angstrom resolution range targeted by ISOLDE) many 
deposited models contain serious errors that are eminently fixable with 
modern tools. My hope is that ISOLDE will become a useful tool allowing 
you to directly inspect your model of interest in the context of its 
original data, providing you with a feasible pathway towards fixing any 
issues you find (or, failing that, moving to a new target) prior to 
committing serious resources to its study.

Please enjoy. Constructive feedback is always welcome.

Best regards,

Tristan



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