= Attendees =

Tom Goddard, Zach, Eric, Greg, Elaine, Scooter, Tom Ferrin

February 26, 2026

= Agenda =

* Jason Gestwicki lab presenting web app for analyzing post-translational modifications
* Endowed viz position search
* Setup of server GPU nodes

= Discussion Notes =

* Chaperone equilibria
 - Jason described 180 human chaperone proteins, their function, and competition for forming many complexes.
 - Saugat Pokhrel, postdoc, showed web app he made to compute abundance of complexes at equilibrium from affinities and abundances of component proteins.
 - Two central proteins are HSP70 and HSP90 (each has variants).
 - CCTPR proteins recognize 5-mer or 10-mer C-terminal on HSP70/90 for binding.
 - Saugat's web app works with 31 CCTPR proteins
 - They have experimental affinity data for about 80% of those.
 - Scooter advised separating backend computation in a REST web service and trying to use existing tools for front-end visualization.

= Action Items =