Some notable milestones in CGL/RBVI's long history include:
- 1965: MIT Project MAC system used to display first interactive molecular structures by Cyrus Levinthal and Robert Langridge
- 1969: Langridge establishes the Computer Graphics Laboratory (CGL) at Princeton University
- 1971: CGL acquires an Evans & Sutherland (E&S) LDS-1 interactive graphics display and a Digital Equipment Corp. (DEC) PDP-10 mainframe computer to drive the display
- 1974: Langridge develops Computer Aided Analysis of Protein Structure (CAAPS) software
- 1976: CGL moves from Princeton to UCSF
- 1976: CGL acquires an E&S Picture System 2 graphics system and DEC PDP-11/70 computer for ~$500,000
- 1978: Molecular Interactive Display System (MIDS) software package for UNIX developed at the CGL by Tom Ferrin, Conrad Huang and Martin Pensak
- 1979: Serial #1 E&S Color Display added to CGL's PS/2
- 1981: First interactive color molecular graphics research studies reported in Science by Langridge, Ferrin, Kuntz and Connolly
- 1985: Annual CGL Holiday Card tradition established
- 1988: CGL's Molecular Interactive Display and Simulation (MIDAS) software first released
- 1993: Langridge retires, Ferrin becomes Lab Director/PI
- 1994: CGL web site created (first web site at UCSF)
- 1995: Development begins on UCSF Chimera
- 2000: CGL renamed to Resource for Biocomputing, Visualization and Informatics (RBVI)
- 2002: UCSF Chimera first released
- 2003: RBVI moves to UCSF Mission Bay Campus
- 2004: UCSF Chimera published in J. Computational Chemistry
- 2005: RBVI's Viz Vault goes live
- 2007: Support for CryoEM density maps added to Chimera
- 2013: Support for 4D light sheet microscopy data sets added to Chimera
- 2016: Number of journal articles citing UCSF Chimera surpasses 10,000 and downloads surpass 500,000
- 2017: First "alpha" release of UCSF ChimeraX
- 2018: Virtual Reality (VR) headset support added to ChimeraX
- 2020: ChimeraX 1.0 released
And here are some of the videos from our collection of historical film clips:
Interactive Molecular Graphics, Thomas Ferrin and Robert Langridge (UCSF), 1980.
Includes van der waals dot surfaces using UCSF BILD, molecular interactions and docking using UCSF MIDS, and a color wheel illustrating capabilites of our new Evans & Sutherland "shadow mask" color calligraphic monitor.
InteractiveMolGraph.mp4 (13:39 minutes -- no audio)
A New Era for Molecular Graphics: Interactive Color Graphics!, Anne Feibelman (Stanford) and Robert Bazell (NBC News), circa 1981.
Includes interviews with Linus Pauling and Robert Language, film illustrating first use of molecular graphics for structure-based drug design, and a short clip showing the molecular graphics sequence created by Langridge for Star Trek II.
A Brief History of Molecular Graphics, Anne Feibelman, circa 1985.
Includes opening animation (i.e., not interactive graphics) illustrating DNA super-helical structure by Nelson Max (LLNL), interviews with Linus Pauling and Robert Language, film from MIT's Project MAC including the first application of interactive molecular graphics, film from Evans & Sutherland LDS-1 graphics system at Princeton University, and interactive docking of a protein with DNA using UCSF MIDAS.
MolGraphics-Feibelman.mp4 (10:41 minutes)
For additional animations created with UCSF Chimera and ChimeraX, see Molecular Animations.
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