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Featured Citations

Illuminating the molecular basis of human daylight vision. Schmidt SL, Dostal J et al. Science. 2026 Jun 25;392(6805):eadz3624.

Vaccination generates broadly cross-neutralizing antibodies to the HIV Env apex. Guenaga J, Ádori M et al. Nature. 2026 Jun 18;654(8119):777–785.

Induction of broadly neutralizing HIV antibodies by a two-step mechanism informs vaccine design. Skelly AN, Gristick HB et al. Science. 2026 Jun 18;392(6804):eaec6396.

Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15. Liang X, Pathak R et al. Proc Natl Acad Sci USA. 2026 Jun 16;123(24):e2607573123.

Structure of the mouse cytoplasmic lattice. Chi P, Wang X et al. Nature. 2026 Jun 10;654(8118):523–531.

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News

June 11, 2026

The ChimeraX 1.12 production release is available! See the change log for what's new.

May 7, 2026

The ChimeraX 1.12 release candidate is available – please try it and report any issues. See the change log for what's new.

December 25, 2025

computer generated image
The RBVI wishes you a safe and happy holiday season! See our 2025 card and the gallery of previous cards back to 1985.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325.

Bluesky logo ChimeraX on Bluesky: @chimerax.ucsf.edu

Feature Highlight

1pho trimer with bfactor coloring/worms

Worms

Worms are specialized cartoons in which “fatness” reflects the values of an attribute such as bfactor or seq_conservation. In the example image, the average atomic B-factor per amino acid residue is shown with both coloring and worms. The structure is a trimer of E. coli porin (PDB 1pho). For image setup, see the command file worms.cxc.

Worms are available in ChimeraX v1.8 daily builds 3/12/24 and newer. Worms and coloring by attribute can be done with the Render by Attribute tool or commands cartoon byattribute (aka worm) and color byattribute.

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Example Image

2015 holiday card with ribosome image

The Human Ribosome

The architecture of the human ribosome has been determined at near-atomic resolution by electron microscopy (Anger et al., Nature 497:80 (2013)). The structure, comprising 82 proteins and five RNA molecules, is shown with shadows cast from all directions to accentuate depth. In the background are schematic representations of contacts between the component molecules.

See the image setup script card.cxc using the 'Tis the Season color palette (credit to MrsP). See also the RBVI holiday card gallery.

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