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Recent Citations

CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome. Shi H, Wang X et al. Nature. 2026 Apr 30;652(8112):1375–1383.

Pre-incision structures reveal principles of DNA nucleotide excision repair. Li ECL, Kim J et al. Nature. 2026 Apr 23;652(8111):1060–1067.

Cryo-EM structure of shutdown human nonmuscle myosin 2A. Casas-Mao D, Carrington G, Peckham M. Sci Adv. 2026 Apr 17;12(16):eaed1858.

Spider venom phospholipase D toxin structure: Interfacial binding site, mechanism, activation, and head group preference. Sundman AK, Binford GJ et al. Proc Natl Acad Sci USA. 2026 Apr 14;123(15):e2513997123.

Regulation of STING activation by phosphoinositide and cholesterol. Li J, Tan JX et al. Nature. 2026 Apr 9;652(8109):499–507.

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News

December 25, 2025

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The RBVI wishes you a safe and happy holiday season! See our 2025 card and the gallery of previous cards back to 1985.

September 22, 2025

Mac users may wish to defer upgrading to MacOS Tahoe. Currently on that OS the Chimera graphics window is shifted so that it covers the command and status lines.

March 6, 2025

Chimera production release 1.19 is now available, fixing the ability to fetch structures from the PDB (1.19 release notes).

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Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.
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UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

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Radial Coloring

A surface can be colored radially, that is, by distance from a user-specified point. Additional options include coloring by distance from an axis or a plane. Different coloring schemes can be applied.

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Gallery Sample

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Orexin Receptor Complex

The image shows the structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant, Protein Data Bank entry 4s0v. The drug is shown as spheres colored by element, and the receptor as ribbons with secondary structure elements rainbow-colored from blue at the N-terminus to red at the C-terminus. (More samples...)


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