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Cysteine carboxyethylation generates neoantigens to induce HLA-restricted autoimmunity. Zhai Y, Chen L et al. Science. 2023 Mar 17;379(6637):eabg2482.

Structure of the human DICER-pre-miRNA complex in a dicing state. Lee YY, Lee H et al. Nature. 2023 Mar 9;615(7951):331–338.

Structure and function of Plasmodium actin II in the parasite mosquito stages. Lopez AJ, Andreadaki M et al. PLoS Pathog. 2023 Mar 6;19(3):e1011174.

Human PRPS1 filaments stabilize allosteric sites to regulate activity. Hvorecny KL, Hargett K et al. Nat Struct Mol Biol. 2023 Mar;30(3):391-402.

In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes. Chen Z, Greenan GA et al. Nat Struct Mol Biol. 2023 Mar;30(3):360-369.

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December 21, 2022

The RBVI wishes you a safe and happy holiday season! See our 2022 card and the gallery of previous cards back to 1985.

September 27, 2022

Website downtime: The RBVI website (Chimera, ChimeraX, etc.) and RBVI-hosted web services will be down for maintenance from Tue, Sep 27 9pm PDT, through Wed, possibly extending to Thu, Sep 29 5pm PDT.

December 20, 2021

The RBVI wishes you a safe and happy holiday season! See our 2021 card and the gallery of previous cards back to 1985.

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Upcoming Events

Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features. ChimeraX includes a significant subset of Chimera features (with more to come, see the missing features list) and is under active development. Users may choose to use both programs, and it is fine to have both installed.

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

Consurf coloring and alignment

Showing ConSurf Results

The ConSurf Server provides results as Chimera Web data; after browser configuration, a single click displays the color-coded query structure and multiple sequence alignment with phylogenetic tree and custom headers in a locally installed copy of Chimera (details).

Special thanks to Elana Erez and the Ben-Tal and Pupko groups at Tel Aviv University, and to Fabian Glaser at the Technion.

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Gallery Sample

Peroxiredoxin Wreath

Peroxiredoxins are enzymes that help cells cope with stressors such as high levels of reactive oxygen species. The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry 1qmv), styled as a holiday wreath.

See also the RBVI holiday card gallery.

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