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Recent Citations

Cryo-electron microscopy structures of human cone visual pigments. Peng Q, Li J et al. Science. 2026 Jun 25;392(6805):eadz8141.

Steric hindrance of antibody binding in an Omicron spike fusion intermediate. Bao Z, Liu Z et al. Nature. 2026 Jun 18;654(8119):762–770.

Structural basis of fungal β-1,3-glucan synthase inhibition by caspofungin. Ren Z, Chhetri A et al. Nature. 2026 Jun 10;654(8118):547–555.

Myosin forces remodel F-actin for mechanosensitive protein recognition. Carl AG, Reynolds MJ et al. Nature. 2026 Jun 4;654(8117):240–249.

A high-throughput selection system for fast-acting covalent protein drugs. Fan Q, Mei J et al. Science. 2026 May 28;392(6801):eadv3081.

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News

June 25, 2026

Chimera production release 1.20 is now available, fixing problems on Mac OS Tahoe (1.20 release notes).

December 25, 2025

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The RBVI wishes you a safe and happy holiday season! See our 2025 card and the gallery of previous cards back to 1985.

September 22, 2025

Mac users may wish to defer upgrading to MacOS Tahoe. Currently on that OS the Chimera graphics window is shifted so that it covers the command and status lines.

Previous news...

Upcoming Events

Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.
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UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

Space Navigator demonstration

Space Navigator Input Device

Space Navigator is an inexpensive ($60) USB input device from 3Dconnexion for moving and rotating models in 3 dimensions. This animation (8 Mb) shows docking a phage enzyme (PDB 1v0e) into an electron microscopy map (EMDB 1333) using a space navigator and mouse. Works with Windows and Mac Chimera versions (details).

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Gallery Sample

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Clathrin

This image of a clathrin cage uses flat shading and edge highlighting. It is a copy of a PDB molecule of the month image made by Graham Johnson and Dave Goodsell. David Goodsell pioneered this visualization style. This image was made with the Multiscale tool, silhouette edging, and surface lighting turned off.

Protein Data Bank model 1xi4.

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