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Featured Citations
Stereochemistry in the disorder-order continuum of protein interactions. Newcombe EA, Due AD et al. Nature. 2024 Dec 19;636(8043):762–768.
MCM double hexamer loading visualized with human proteins. Weissmann F, Greiwe JF et al. Nature. 2024 Dec 12;636(8042):499–508.
Multiple mechanisms for licensing human replication origins. Yang R, Hunker O et al. Nature. 2024 Dec 12;636(8042):488–498.
Molecular sociology of virus-induced cellular condensates supporting reovirus assembly and replication. Liu X, Xia X et al. Nat Commun. 2024 Dec 6;15(1):10638.
Broadly inhibitory antibodies to severe malaria virulence proteins. Reyes RA, Raghavan SSR et al. Nature. 2024 Dec 5;635(8041):182–189.
More citations...News
December 12, 2024
The ChimeraX 1.9 production release is available! See the change log for what's new.
October 14, 2024
Planned downtime: The ChimeraX website, Toolshed, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable starting Monday, Oct 14 10 AM PDT, continuing throughout the week and potentially the weekend (Oct 14-20).
August 1, 2024
Planned downtime: The ChimeraX website, Toolshed, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable August 1, 3-6 pm PDT.
Previous news...Upcoming Events
UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.
ChimeraX is developed with support from National Institutes of Health R01-GM129325, Chan Zuckerberg Initiative grant EOSS4-0000000439, and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.
Feature Highlight
Worms are specialized cartoons in which “fatness” reflects the values of an attribute such as bfactor or seq_conservation. In the example image, the average atomic B-factor per amino acid residue is shown with both coloring and worms. The structure is a trimer of E. coli porin (PDB 1pho). For image setup, see the command file worms.cxc.
Worms are available in ChimeraX v1.8 daily builds 3/12/24 and newer. Worms and coloring by attribute can be done with the Render by Attribute tool or commands cartoon byattribute (aka worm) and color byattribute.
More features...Example Image
Atomic B-factor values are read from PDB and mmCIF input files and assigned as attributes that can be shown with coloring and used in atom specification. This example shows B-factor variation within a structure of the HIV-1 protease bound to an inhibitor (PDB 4hvp). For complete image setup, including positioning, color key, and label, see the command file bfactor.cxc.
Additional color key examples can be found in tutorials: Coloring by Electrostatic Potential, Coloring by Sequence Conservation
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