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Tracking transcription-translation coupling in real time. Qureshi NS, Duss O. Nature. 2025 Jan 9;637(8045):487–495.
Autoinhibition of dimeric NINJ1 prevents plasma membrane rupture. Pourmal S, Truong ME et al. Nature. 2025 Jan 9;637(8045):446–452.
Dual-action kinase inhibitors influence p38α MAP kinase dephosphorylation. Stadnicki EJ, Ludewig H et al. Proc Natl Acad Sci USA. 2025 Jan 7;122(1):e2415150122.
Chemical bond overlap descriptors from multiconfiguration wavefunctions. Santos-Jr CV, Kraka E, Moura RT Jr. J Comput Chem. 2025 Jan 5;46(1):e27534.
Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease. Fowler SL, Behr TS et al. Nat Neurosci. 2025 Jan;28(1):40-48.
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December 25, 2024
December 12, 2024
The ChimeraX 1.9 production release is available! See the change log for what's new.
October 14, 2024
Planned downtime: The ChimeraX website, Toolshed, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable starting Monday, Oct 14 10 AM PDT, continuing throughout the week and potentially the weekend (Oct 14-20).
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UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.
ChimeraX is developed with support from National Institutes of Health R01-GM129325, Chan Zuckerberg Initiative grant EOSS4-0000000439, and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.
Feature Highlight
Atomic structures, including cartoons and molecular surfaces, can be colored by the conservation in an associated multiple sequence alignment. The figure shows a structure of the β2-adrenergic receptor signaling complex (PDB 3sn6) with receptor cartoon colored blue→white→red from least conserved to most conserved. The β2-adrenergic receptor is a member of the class A G-protein-coupled receptor superfamily. Conservation was calculated from a superfamily alignment from PASS2 using the entropy-based measure from AL2CO (included with ChimeraX courtesy of Pei and Grishin). The sequence alignment and step-by-step instructions for making this image are given in the Coloring by Sequence Conservation tutorial.
More features...Example Image
Calmodulin (CaM) acts as a calcium sensor. When its four Ca++ sites are fully occupied, it binds and modulates the activity of various downstream proteins, including CaM-dependent protein kinase I (CaMKI). Here, a complex between CaM and its target peptide from CaMKI (PDB 1mxe) is shown with cartoons, a transparent molecular surface, silhouette outlines, and light soft ambient occlusion. (If you prefer a less smudgy/rustic appearance, try using light gentle instead.) For image setup other than positioning, see the command file cam.cxc.
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