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Featured Citations

Human and bacterial genetic variation shape oral microbiomes and health. Kamitaki N, Handsaker RE et al. Nature. 2026 Mar 12;651(8105):429-439.

Programmable genome editing in human cells using RNA-guided bridge recombinases. Pelea O, Tálas A et al. Science. 2026 Mar 12;391(6790):eadz1884.

Megabase-scale human genome rearrangement with programmable bridge recombinases. Perry NT, Bartie LJ et al. Science. 2026 Mar 12;391(6790):eadz0276.

De novo design of GPCR exoframe modulators. Cheng S, Guo J et al. Nature. 2026 Mar 5;651(8104):242–250.

Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2. Taylor MS, Chen M et al. Science. 2026 Mar 5;(6789):eadv7111.

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News

December 25, 2025

computer generated image
The RBVI wishes you a safe and happy holiday season! See our 2025 card and the gallery of previous cards back to 1985.

December 16, 2025

The ChimeraX 1.11 production release is available! See the change log for what's new.

November 21, 2025

The ChimeraX 1.11 release candidate is available – please try it and report any issues. See the change log for what's new. This will be the last release to support Red Hat Enterprise Linux 8 and its derivatives.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325.

Bluesky logo ChimeraX on Bluesky: @chimerax.ucsf.edu

Feature Highlight

2gbp kvfinder cavities

Find Cavities

Pockets and cavities in protein structures can be identified with the Find Cavities tool or kvfinder command. These run KVFinder, a method based on surface shape developed by the Lopes-de-Oliveira group at the Brazilian Biosciences National Laboratory (details...).

As shown in the figure, the results are listed in an interactive cavity list and can be displayed as dot clouds and/or surfaces.

The latest iteration of this feature is available in ChimeraX 1.10 daily builds 4/17/25 and newer. For image setup other than position and the specific cavity colors (which are assigned randomly after a calculation), see the command file kvfinder.cxc.

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Example Image

photosynthetic reaction center

Photosynthetic Reaction Center

The photosynthetic reaction center from a purple sulfur bacterium is shown as a cartoon with “tube” helices and membrane boundaries from the OPM database (Orientations of Proteins in Membranes, entry 1eys). Blue and red balls represent the cytoplasmic and periplasmic sides of the bacterial inner membrane, respectively. The title and other text labels were added with the 2dlabels command and repositioned interactively with the move label mouse mode computer generated image. ChimeraX session file: prc.cxs

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