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Citations (partial list)

Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases. Kondo Y, Ognjenović J et al. Science. 2019 Oct 4;366(6461):109-115.

Structural insights into TRPM8 inhibition and desensitization. Diver MM, Cheng Y, Julius D. Science. 2019 Sep 27;365(6460):1434-1440.

Universal activation index for class A GPCRs. Ibrahim P, Wifling D, Clark T. J Chem Inf Model. 2019 Sep 23;59(9):3938-3945.

Structural basis for inhibition of human primase by arabinofuranosyl nucleoside analogues fludarabine and vidarabine. Holzer S, Rzechorzek NJ et al. ACS Chem Biol. 2019 Sep 20;14(9):1904-1912.

Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle. Brouwer PJM, Antanasijevic A et al. Nat Commun. 2019 Sep 19;10(1):4272.

Hydrophobic gasket mutation produces gating pore currents in closed human voltage-gated proton channels. Banh R, Cherny VV et al. Proc Natl Acad Sci USA. 2019 Sep 17;116(38):18951-18961.

Tuning metal-metal interactions through reversible ligand folding in a series of dinuclear iron complexes. Zhang S, Wang Q et al. Inorg Chem. 2019 Sep 16;58(18):12234-12244.

Structures of influenza A virus RNA polymerase offer insight into viral genome replication. Fan H, Walker AP et al. Nature. 2019 Sep 12;573(7773):287-290.

Regulation of Eag1 gating by its intracellular domains. Whicher JR, MacKinnon R. eLife. 2019 Sep 6;8. pii: e49188.

The 4-electron cleavage of a N═N double bond by a trimetallic TiNi2 complex. Dunn PL, Chatterjee S et al. Inorg Chem. 2019 Sep 3;58(17):11762-11772.

The central role of the tail in switching off 10S myosin II activity. Yang S, Lee KH et al. J Gen Physiol. 2019 Sep 2;151(9):1081-1093.

Current understanding of the role of neuronal calcium sensor 1 in neurological disorders. Bandura J, Feng ZP. Mol Neurobiol. 2019 Sep;56(9):6080-6094.

Methods for merging data sets in electron cryo-microscopy. Wilkinson ME, Kumar A, Casañal A. Acta Crystallogr D Struct Biol. 2019 Sep 1;75(Pt 9):782-791.

Atomic structure of the Epstein-Barr virus portal. Machón C, Fàbrega-Ferrer M et al. Nat Commun. 2019 Aug 29;10(1):3891.

Structural and functional analyses of photosystem II in the marine diatom Phaeodactylum tricornutum. Levitan O, Chen M et al. Proc Natl Acad Sci USA. 2019 Aug 27;116(35):17316-17322.

Structure and conformational plasticity of the intact Thermus thermophilus V/A-type ATPase. Zhou L, Sazanov LA. Science. 2019 Aug 23;365(6455). pii: eaaw9144.

Structures of the rhodopsin-transducin complex: Insights into G-protein activation. Gao Y, Hu H et al. Mol Cell. 2019 Aug 22;75(4):781-790.e3.

Modulation of cardiac ryanodine receptor 2 by calmodulin. Gong D, Chi X et al. Nature. 2019 Aug 15;572(7769):347-351.

In situ structures of RNA-dependent RNA polymerase inside bluetongue virus before and after uncoating. He Y, Shivakoti S et al. Proc Natl Acad Sci USA. 2019 Aug 13;116(33):16535-16540.

Exit tunnel modulation as resistance mechanism of S. aureus erythromycin resistant mutant. Halfon Y, Matzov D et al. Sci Rep. 2019 Aug 7;9(1):11460.

Continuous Evaluation of Ligand Protein Predictions: A weekly community challenge for drug docking. Wagner JR, Churas CP et al. Structure. 2019 Aug 6;27(8):1326-1335.e4.

A visualization tool for cryo-EM protein validation with an unsupervised machine learning model in Chimera platform. Chen L, Baker B et al. Medicines. 2019 Aug 6; 6(3):86.

Structure of the Cdc48 segregase in the act of unfolding an authentic substrate. Cooney I, Han H et al. Science. 2019 Aug 2;365(6452):502-505.

Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding. Twomey EC, Ji Z et al. Science. 2019 Aug 2;365(6452). pii: eaax1033.

The pigment-protein network of a diatom photosystem II-light-harvesting antenna supercomplex. Pi X, Zhao S et al. Science. 2019 Aug 2;365(6452). pii: eaax4406.

A cryo-FIB lift-out technique enables molecular-resolution cryo-ET within native Caenorhabditis elegans tissue. Schaffer M, Pfeffer S et al. Nat Methods. 2019 Aug;16(8):757-762.

Identification of Ebola virus inhibitors targeting GP2 using principles of molecular mimicry. Singleton CD, Humby MS et al. J Virol. 2019 Aug 1;93(15). pii: e00676-19.

Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1. Faelber K, Dietrich L et al. Nature. 2019 Jul 18;571(7765):429-433.

Structural basis for the adsorption of a single-stranded RNA bacteriophage. Meng R, Jiang M et al. Nat Commun. 2019 Jul 16;10(1):3130.

Structural visualization of key steps in nucleosome reorganization by human FACT. Mayanagi K, Saikusa K et al. Sci Rep. 2019 Jul 15;9(1):10183.

Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi. Qi X, Liu H et al. Nature. 2019 Jul 11;571(7764):279-283.

Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble. Liu TY, Liu JJ et al. Nat Commun. 2019 Jul 5;10(1):3001.

Large plasticity in magnesium mediated by pyramidal dislocations. Liu BY, Liu F et al. Science. 2019 Jul 5;365(6448):73-75.

Arabinose alters both local and distal H-D exchange rates in the Escherichia coli AraC transcriptional regulator. Tischer A, Brown MJ et al. Biochemistry. 2019 Jul 2;58(26):2875-2882.

Fusion of DARPin to aldolase enables visualization of small protein by cryo-EM. Yao Q, Weaver SJ et al. Structure. 2019 Jul 2;27(7):1148-1155.e3.

Biological adaptations in the Arctic cervid, the reindeer (Rangifer tarandus). Lin Z, Chen L et al. Science. 2019 Jun 21;364(6446). pii: eaav6312.

Two-step activation mechanism of the ClpB disaggregase for sequential substrate threading by the main ATPase motor. Deville C, Franke K et al. Cell Rep. 2019 Jun 18;27(12):3433-3446.e4.

Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1. Gu J, Zhang L et al. Science. 2019 Jun 14;364(6445):1068-1075.

In situ structure and assembly of the multidrug efflux pump AcrAB-TolC. Shi X, Chen M et al. Nat Commun. 2019 Jun 14;10(1):2635.

Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome. Liu YT, Jih J et al. Nature. 2019 Jun 13;570(7760):257-261.

Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus. Ilca SL, Sun X et al. Nature. 2019 Jun 13;570(7760):252-256.

The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy. Fu Z, Indrisiunaite G et al. Nat Commun. 2019 Jun 12;10(1):2579.

Multifunctional graphene supports for electron cryomicroscopy. Naydenova K, Peet MJ, Russo CJ. Proc Natl Acad Sci USA. 2019 Jun 11;116(24):11718-11724.

Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism. Fumagalli M, Camus SM et al. eLife. 2019 Jun 4;8. pii: e41517.

Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin. Grushin K, Wang J et al. Nat Commun. 2019 Jun 3;10(1):2413.

The structure of the stress-induced photosystem I-IsiA antenna supercomplex. Toporik H, Li J et al. Nat Struct Mol Biol. 2019 Jun;26(6):443-449.

Structural dynamics of bacteriophage P22 infection initiation revealed by cryo-electron tomography. Wang C, Tu J et al. Nat Microbiol. 2019 Jun;4(6):1049-1056.

Breaking the law: unconventional strategies for antibody diversification. Kanyavuz A, Marey-Jarossay A et al. Nat Rev Immunol. 2019 Jun;19(6):355-368.

In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release. Ding K, Celma CC et al. Nat Commun. 2019 May 17;10(1):2216.

An ultra-stable gold-coordinated protein cage displaying reversible assembly. Malay AD, Miyazaki N et al. Nature. 2019 May 16;569(7756):438-442.

Predicting protein dimer structures using MELD × MD. Brini E, Kozakov D, Dill KA. J Chem Theory Comput. 2019 May 14;15(5):3381-3389.

Structure of the Ty3/Gypsy retrotransposon capsid and the evolution of retroviruses. Dodonova SO, Prinz S et al. Proc Natl Acad Sci USA. 2019 May 14;116(20):10048-10057.

Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes. Maeda S, Qu Q et al. Science. 2019 May 10;364(6440):552-557.

Visualization of clustered protocadherin neuronal self-recognition complexes. Brasch J, Goodman KM et al. Nature. 2019 May 9;569(7755):280-283.

Three-dimensional architecture of epithelial primary cilia. Sun S, Fisher RL et al. Proc Natl Acad Sci USA. 2019 May 7;116(19):9370-9379.

Integrating Hi-C and FISH data for modeling of the 3D organization of chromosomes. Abbas A, He X et al. Nat Commun. 2019 May 3;10(1):2049.

A compact synthetic pathway rewires cancer signaling to therapeutic effector release. Chung HK, Zou X et al. Science. 2019 May 3;364(6439). pii: eaat6982.

eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response. Kenner LR, Anand AA et al. Science. 2019 May 3;364(6439):491-495.

Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport. Coleman JA, Yang D et al. Nature. 2019 May 2;569(7754):141-145.

Atomic structure of the translation regulatory protein NS1 of bluetongue virus. Kerviel A, Ge P et al. Nat Microbiol. 2019 May;4(5):837-845.

Designing a chemical inhibitor for the AAA protein spastin using active site mutations. Cupido T, Pisa R et al. Nat Chem Biol. 2019 May;15(5):444-452.

Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP γ8. Herguedas B, Watson JF et al. Science. 2019 Apr 26;364(6438):eaav9011.

Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM. Zhao Y, Chen S et al. Science. 2019 Apr 26;364(6438):eaaw8250.

An allosteric mechanism for potent inhibition of human ATP-citrate lyase. Wei J, Leit S et al. Nature. 2019 Apr 25;568(7753):566-570.

Retrieving high-resolution information from disordered 2D crystals by single-particle cryo-EM. Righetto RD, Biyani N et al. Nat Commun. 2019 Apr 12;10(1):1722.

Structure and dynamics of the active human parathyroid hormone receptor-1. Zhao LH, Ma S et al. Science. 2019 Apr 12;364(6436):148-153.

Ligand-triggered allosteric ADP release primes a plant NLR complex. Wang J, Wang J et al. Science. 2019 Apr 5;364(6435). pii: eaav5868.

The phage L capsid decoration protein has a novel OB-fold and an unusual capsid binding strategy. Newcomer RL, Schrad JR et al. eLife. 2019 Apr 4;8. pii: e45345.

De novo structural pattern mining in cellular electron cryotomograms. Xu M, Singla J et al. Structure. 2019 Apr 2;27(4):679-691.e14.

Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry. Guo M, Zhang K et al. Cell Res. 2019 Apr;29(4):305-312.

Structural basis of lipopolysaccharide extraction by the LptB2FGC complex. Li Y, Orlando BJ, Liao M. Nature. 2019 Mar 28;567(7749):486-490.

3D printed absorber for capturing chemotherapy drugs before they spread through the body. Oh HJ, Aboian MS et al. ACS Cent Sci. 2019 Mar 27;5(3):419-427.

Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins. Shen H, Liu D et al. Science. 2019 Mar 22;363(6433):1303-1308.

Mechanism of DNA translocation underlying chromatin remodelling by Snf2. Li M, Xia X et al. Nature. 2019 Mar 21;567(7748):409-413.

Structural basis of STING binding with and phosphorylation by TBK1. Zhang C, Shang G et al. Nature. 2019 Mar 21;567(7748):394-398.

Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis. Radamaker L, Lin YH et al. Nat Commun. 2019 Mar 20;10(1):1103.

Ligand entry in human ileal bile acid-binding protein is mediated by histidine protonation. Horváth G, Egyed O et al. Sci Rep. 2019 Mar 18;9(1):4825.

Global computational mutagenesis of domain structures associated with inherited eye disease. Ortiz FW, Sergeev YV. Sci Rep. 2019 Mar 6;9(1):3676.

Mechanism of actin polymerization revealed by cryo-EM structures of actin filaments with three different bound nucleotides. Chou SZ, Pollard TD. Proc Natl Acad Sci USA. 2019 Mar 5;116(10):4265-4274.

Cryo-EM of retinoschisin branched networks suggests an intercellular adhesive scaffold in the retina. Heymann JB, Vijayasarathy C et al. J Cell Biol. 2019 Mar 4;218(3):1027-1038.

Assessing the predictive power of relative binding free energy calculations for test cases involving displacement of binding site water molecules. Wahl J, Smieško M. J Chem Inf Model. 2019 Feb 25;59(2):754-765.

Circadian oscillator proteins across the kingdoms of life: structural aspects. Saini R, Jaskolski M, Davis SJ. BMC Biol. 2019 Feb 18;17(1):13.

CasX enzymes comprise a distinct family of RNA-guided genome editors. Liu JJ, Orlova N et al. Nature. 2019 Feb 14;566(7743):218-223.

Structural basis for recognition of ubiquitylated nucleosome by Dot1L methyltransferase. Anderson CJ, Baird MR et al. Cell Rep. 2019 Feb 12;26(7):1681-1690.e5.

Electron cryo-tomography provides insight into procentriole architecture and assembly mechanism. Li S, Fernandez JJ et al. eLife. 2019 Feb 11;8. pii: e43434.

Chemoinformatics and structural bioinformatics in OCaml. Berenger F, Zhang KYJ, Yamanishi Y. J Cheminform. 2019 Feb 5;11(1):10.

A multi-model approach to assessing local and global cryo-EM map quality. Herzik MA Jr, Fraser JS, Lander GC. Structure. 2019 Feb 5;27(2):344-358.e3.

Noncompetitive antagonists induce cooperative AMPA receptor channel gating. Shi EY, Yuan CL et al. J Gen Physiol. 2019 Feb 4;151(2):156-173.

The path of pre-ribosomes through the nuclear pore complex revealed by electron tomography. Delavoie F, Soldan V et al. Nat Commun. 2019 Jan 30;10(1):497.

FGF21 trafficking in intact human cells revealed by cryo-electron tomography with gold nanoparticles. Azubel M, Carter SD et al. eLife. 2019 Jan 28;8. pii: e43146.

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Whitesell L, Robbins N et al. Nat Commun. 2019 Jan 24;10(1):402.

GABAA receptor signalling mechanisms revealed by structural pharmacology. Masiulis S, Desai R et al. Nature. 2019 Jan 24;565(7740):454-459.

Chemical cross-linking enables drafting ClpXP proximity maps and taking snapshots of in situ interaction networks. Fux A, Korotkov VS et al. Cell Chem Biol. 2019 Jan 17;26(1):48-59.e7.

Domain insertion permissibility-guided engineering of allostery in ion channels. Coyote-Maestas W, He Y et al. Nat Commun. 2019 Jan 17;10(1):290.

Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association. Kukuk L, Dingley AJ et al. Sci Rep. 2019 Jan 10;9(1):54.

Structure of the posttranslational Sec protein-translocation channel complex from yeast. Itskanov S, Park E. Science. 2019 Jan 4;363(6422):84-87.

Structures of TRPV2 in distinct conformations provide insight into role of the pore turret. Dosey TL, Wang Z et al. Nat Struct Mol Biol. 2019 Jan;26(1):40-49.

Polarized displacement by transcription activator-like effectors for regulatory circuits. Lebar T, Verbič A et al. Nat Chem Biol. 2019 Jan;15(1):80-87.

Structure of human TFIID and mechanism of TBP loading onto promoter DNA. Patel AB, Louder RK et al. Science. 2018 Dec 21;362(6421). pii: eaau8872.

Structure of native lens connexin 46/50 intercellular channels by cryo-EM. Myers JB, Haddad BG et al. Nature. 2018 Dec 20;564(7736):372-377.

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