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Featured Citations

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase. Verba KA, Wang RY et al. Science. 2016 Jun 24;352(6293):1542-7.

Structure and membrane remodeling activity of ESCRT-III helical polymers. McCullough J, Clippinger AK et al. Science. 2015 Dec 18;350(6267):1548-51.

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News

July 18, 2017

Our ChimeraX paper is accessible online! UCSF ChimeraX: Meeting modern challenges in visualization and analysis. Goddard TD, Huang CC et al.. Protein Sci. 2017, in press.

March 28, 2017

An alpha release of ChimeraX is available (Mac, Linux, Windows). For information on features, please see the documentation.

December 22, 2016

ChimeraX pre-release daily builds are available!

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see licensing.

ChimeraX development is funded by the National Institutes of Health (NIGMS P41-GM103311).

Feature Highlight

membrane protein with lipophilicity coloring

Coloring by Molecular Lipophilicity Potential

Molecular lipophilicity potential (MLP) can be calculated for a protein and shown with surface coloring using the command mlp. The outer-membrane protein CymA allows the diffusion of bulky molecules into the periplasmic space of Klebsiella oxytoca. The image shows CymA (PDB 4d5d chain A) with an α-cyclodextrin molecule (purple) bound at the entry site; a β-cyclodextrin molecule (not visible) is bound inside, near the other end of the pore. The surface coloring ranges from dark goldenrod for the most hydrophobic potentials, through white, to dark cyan for the most hydrophilic. This coloring and the binding of detergent molecules (pink) together help to identify the membrane-embedded portion of the protein. For image setup other than orientation, see the command file mlp.cxc.

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Example Image

neuraminidase flowers

Neuraminidase Flowers

Influenza neuraminidase is an enzyme that promotes the spread of influenza virus among host cells. It is the target of oseltamivir and related antiviral drugs. The image shows tetramers of neuraminidase (PDB 3k3a) styled as flowers. Three tetramers are in different shades of pink, with a central metal ion in white and nearby residues in yellow, and a fourth tetramer is colored green to resemble leaves. Each monomer or “petal” is a six-bladed β-propeller. For image setup other than orientation, see the command file flowers.cxc. The Chimera Image Gallery includes a similar image.

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