Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase. Verba KA, Wang RY et al. Science. 2016 Jun 24;352(6293):1542-7.
Structure and membrane remodeling activity of ESCRT-III helical polymers. McCullough J, Clippinger AK et al. Science. 2015 Dec 18;350(6267):1548-51.See also RCSB PDB images...
March 28, 2017
December 22, 2016
ChimeraX pre-release daily builds are available!
June 4 and 7, 2017
Tristan Croll will lead workshop sessions on his ChimeraX plugin ISOLDE (for interactive structure refinement) at the EMBO course on Integrative Structural Biology (June 3-10 in Erice, Italy).
UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see licensing.
ChimeraX development is funded by the National Institutes of Health (NIGMS P41-GM103311).
Molecular lipophilicity potential (MLP) can be calculated for a protein and shown with surface coloring using the command mlp. The outer-membrane protein CymA allows the diffusion of bulky molecules into the periplasmic space of Klebsiella oxytoca. The image shows CymA (PDB 4d5d chain A) with an α-cyclodextrin molecule (purple) bound at the entry site; a β-cyclodextrin molecule (not visible) is bound inside, near the other end of the pore. The surface coloring ranges from dark goldenrod for the most hydrophobic potentials, through white, to dark cyan for the most hydrophilic. This coloring and the binding of detergent molecules (pink) together help to identify the membrane-embedded portion of the protein. For image setup other than orientation, see the command file mlp.cxc.More features...
The architecture of the human ribosome has been determined at near-atomic resolution by electron microscopy (Anger et al., Nature 497:80 (2013)). The structure, comprising 82 proteins and five RNA molecules, is shown with shadows cast from all directions to accentuate depth. In the background are schematic representations of contacts between the component molecules.