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Inherent symmetry and flexibility in hepatitis B virus subviral particles. Wang Q, Wang T et al. Science. 2024 Sep 13;385(6714):1217-1224.
Substrate binding and inhibition mechanism of norepinephrine transporter. Ji W, Miao A et al. Nature. 2024 Sep 12;633(8029):473–479.
In situ structure and rotary states of mitochondrial ATP synthase in whole Polytomella cells. Dietrich L, Agip AA et al. Science. 2024 Sep 6;385(6713):1086-1090.
Structural basis for transthiolation intermediates in the ubiquitin pathway. Kochańczyk T, Hann ZS et al. Nature. 2024 Sep 5;633(8028):216–223.
Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site. Caniels TG, Medina-Ramìrez M et al. Sci Immunol. 2024 Aug 30;9(98):eadk9550.
More citations...News
August 1, 2024
Planned downtime: The ChimeraX website, Toolshed, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable August 1, 3-6 pm PDT.
June 17-18, 2024
Planned downtime: The ChimeraX website, Toolshed, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable June 17-18 PDT.
June 13, 2023
The ChimeraX 1.8 production release is available! See the change log for what's new.
Previous news...Upcoming Events
UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.
ChimeraX is developed with support from National Institutes of Health R01-GM129325, Chan Zuckerberg Initiative grant EOSS4-0000000439, and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.
Feature Highlight
3D images and time series from multichannel optical microscopy are shown in the Volume Viewer tool, with easy access to hiding/showing individual channels, changing their colors, and adjusting threshold levels with the mouse. The menu of style options includes “volume” (translucent blobs, as in the image), surface, mesh, maximum intensity projection, single plane, and orthoplanes. For convenience, the step size, region bounds, and display style of different channels of the same dataset are coupled, in that changing the setting of one channel automatically changes it for the others.
The image shows human induced pluripotent stem cells, with plasma membrane in violet red, EGFP-tagged fibrillarin (as a marker for nucleolus) in yellow, and DNA (nucleus) in turquoise. The data are publicly available from the Allen Cell Explorer website, dataset: AICS-14_0.
More features...Example Image
Calmodulin (CaM) acts as a calcium sensor. When its four Ca++ sites are fully occupied, it binds and modulates the activity of various downstream proteins, including CaM-dependent protein kinase I (CaMKI). Here, a complex between CaM and its target peptide from CaMKI (PDB 1mxe) is shown with cartoons, a transparent molecular surface, silhouette outlines, and light soft ambient occlusion. (If you prefer a less smudgy/rustic appearance, try using light gentle instead.) For image setup other than positioning, see the command file cam.cxc.
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