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CRISPR RNA-guided autonomous delivery of Cas9. Wilkinson RA, Martin C et al. Nat Struct Mol Biol. 2019 Jan;26(1):14-24.

Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly. Leung MR, van Bezouwen LS et al. Proc Natl Acad Sci USA. 2018 Dec 26;115(52):13270-13275.

Structure of the type VI secretion system TssK-TssF-TssG baseplate subcomplex revealed by cryo-electron microscopy. Park YJ, Lacourse KD et al. Nat Commun. 2018 Dec 19;9(1):5385.

Microtubule structure by cryo-EM: snapshots of dynamic instability. Manka SW, Moores CA. Essays Biochem. 2018 Dec 7;62(6):737-751.

Substrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation. de la Peña AH, Goodall EA et al. Science. 2018 Nov 30;362(6418). pii: eaav0725.

See also: RCSB PDB Images
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News

December 17, 2018

ChimeraX version 0.8 is available. See the change log for what's new.

August 7, 2018

ChimeraX version 0.7 is available. See the change log for what's new.

July 13, 2018

New Virtual Reality at UCSF website shares information on VR projects, resources, and related issues.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see licensing.

ChimeraX development is supported in part by grants from the National Institutes of Health (currently R01-GM129325, previously P41-GM103311).

Feature Highlight

4hhb ambient lighting

Ambient Occlusion Molecular Surfaces

Several lighting modes are available, including ambient occlusion. The image shows hemoglobin (PDB 4hhb) with the four chains shown as surfaces of different colors and heme residues as spheres. The command lighting soft or the Graphics sugar-cube icon can be used to turn on ambient shadowing from 64 directions. The command lighting gentle gives a similar result, except tuned to emphasize larger indentations.

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Example Image

The Human Ribosome

The architecture of the human ribosome has been determined at near-atomic resolution by electron microscopy (Anger et al., Nature 497:80 (2013)). The structure, comprising 82 proteins and five RNA molecules, is shown with shadows cast from all directions to accentuate depth. In the background are schematic representations of contacts between the component molecules.

See the image setup script card.cxc using the 'Tis the Season color palette (credit to MrsP). See also the RBVI holiday card gallery.

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