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Featured Citations

Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin. Piper SJ, Brillault L et al. Nat Commun. 2019 Apr 26;10(1):1952.

Structure reveals a mechanism of CRISPR-RNA-guided nuclease recruitment and anti-CRISPR viral mimicry. Rollins MF, Chowdhury S et al. Mol Cell. 2019 Apr 4;74(1):132-142.e5.

Protein denaturation at the air-water interface and how to prevent it. D'Imprima E, Floris D et al. eLife. 2019 Apr 1;8. pii: e42747.

Structural snapshots of 26S proteasome reveal tetraubiquitin-induced conformations. Ding Z, Xu C et al. Mol Cell. 2019 Mar 21;73(6):1150-1161.e6.

Unexpected receptor functional mimicry elucidates activation of coronavirus fusion. Walls AC, Xiong X et al. Cell. 2019 Feb 21;176(5):1026-1039.e15.

See also: RCSB PDB Images
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News

June 6, 2019

The ChimeraX 0.9 production release is available. See the change log for what's new.

May 30, 2019

From the Rochester Institute of Technology: Student develops tool to visualize molecular dynamics of proteins in virtual reality with ChimeraX.

May 23, 2019

A ChimeraX 0.9 release candidate is available – please try it and report any issues.

Previous news...

Upcoming Events

July 10, 2019

Tom Goddard will lead a ChimeraX-cryoEM session at the S2C2 Modeling Workshop (Stanford-SLAC Cryo-EM Center, July 10-12, 2019). Apply to workshop...


UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see licensing.

ChimeraX development is supported in part by the National Institute of General Medical Sciences (R01-GM129325; previously P41-GM103311) and the National Institute of Allergy and Infectious Diseases.

Feature Highlight

Elp2 fit into map of Elongator subcomplex

Fitting to Density Maps

Atomic structures and/or maps can be fit rigidly into other maps with the fitmap command or the Map icon . A common use is to locally optimize the fit after initial placement by hand. Options include symmetrical and sequential fitting, as well as global search to generate multiple starting points for local optimization.

Elongator is a highly conserved complex that associates with RNA polymerase II during transcriptional elongation. In the image, one of its six subunits, Elp2 (PDB 5m2n), has been fit into a map of the Elp123 subcomplex (EMDB 4151).

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Example Image

neuraminidase flowers

Neuraminidase Flowers

Influenza neuraminidase is an enzyme that promotes the spread of influenza virus among host cells. It is the target of oseltamivir and related antiviral drugs. The image shows tetramers of neuraminidase (PDB 3k3a) styled as flowers. Three tetramers are in different shades of pink, with a central metal ion in white and nearby residues in yellow, and a fourth tetramer is colored green to resemble leaves. Each monomer or “petal” is a six-bladed β-propeller. For image setup other than orientation, see the command file flowers.cxc. The Chimera Image Gallery includes a similar image.

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