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Featured Citations

Active site rearrangement and structural divergence in prokaryotic respiratory oxidases. Safarian S, Hahn A et al. Science. 2019 Oct 4;366(6461):100-104.

A unified mechanism for intron and exon definition and back-splicing. Li X, Liu S et al. Nature. 2019 Sep 19;573(7774):375-380.

Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery. Saurer M, Ramrath DJF et al. Science. 2019 Sep 13;365(6458):1144-1149.

CryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation. Wongpalee SP, Liu S et al. Nat Commun. 2019 Sep 2;10(1):3916.

Structure of the dynein-2 complex and its assembly with intraflagellar transport trains. Toropova K, Zalyte R et al. Nat Struct Mol Biol. 2019 Sep;26(9):823-829.

See also: RCSB PDB Images
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News

October 16, 2019

ChimeraX virtual reality featured in UCSF School of Pharmacy news: VR Drug Discovery Makes Precision Therapy a Reality  [video]

June 20, 2019

ChimeraX virtual reality shown on PBS Newshour: How Close are Scientists to a Universal Flu Vaccine?

June 6, 2019

The ChimeraX 0.9 production release is available. See the change log for what's new.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325 and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.

Feature Highlight

simple lighting soft lighting

cryoEM Ambient Occlusion

A cryoelectron microscopy map of the 26S proteasome (EMD-4321) is shown at the author-recommended contour level in two different lighting modes: “simple” on the left and “soft” on the right. Soft lighting includes ambient lighting and shadowing (occlusion) and can be turned on with the command lighting soft or by clicking the Graphics icon .

For setup of the righthand image, see the command file ambient.cxc.

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Example Image

transducin switch regions

G-Protein Switch Regions

The GDP- and GTP-bound conformations of the transducin α-subunit (1tag and 1tnd, respectively) differ primarily in three regions, termed switch 1, switch 2, and switch 3. The structures have been superimposed with matchmaker and shown as cartoons, with “empty” outlines where the structures are almost the same (for simplicity, only one conformation's outlines are shown). The GTP analog GTPγS is displayed as spheres color-coded by heteroatom. For 2D labels and image setup other than structure orientation, see the command file switch.cxc.

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