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Structural pathway for PI3-kinase regulation by VPS15 in autophagy. Cook ASI, Chen M et al. Science. 2025 Apr 11;388(6743):eadl3787.

A coronavirus assembly inhibitor that targets the viral membrane protein. Laporte M, Jochmans D et al. Nature. 2025 Apr 10;640(8058):514–523.

Cytoplasmic ribosomes on mitochondria alter the local membrane environment for protein import. Chang YT, Barad BA et al. J Cell Biol. 2025 Apr 7;224(4):e202407110.

Running a genetic stop sign accelerates oxygen metabolism and energy production in horses. Castiglione GM, Chen X et al. Science. 2025 Mar 28;387(6741):eadr8589.

Structural basis for the pore-forming activity of a complement-like toxin. Johnstone BA, Christie MP et al. Sci Adv. 2025 Mar 28;11(13):eadt2127.

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News

March 19, 2025

Wiley most-cited-paper medallion
UCSF ChimeraX: Tools for structure building and analysis is one of the 10 most cited papers published in Protein Science in 2023!

March 1, 2025

Bluesky logo Follow UCSF ChimeraX on BlueSky! @chimerax.ucsf.edu

December 25, 2024

The RBVI wishes you a safe and happy holiday season! See our 2024 card and the gallery of previous cards back to 1985.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325.

Bluesky logo ChimeraX on Bluesky: @chimerax.ucsf.edu

Feature Highlight

AMPA receptor with tube helices

Curved Helix Cylinders

Protein α-helices can be shown as curved-cylinder “tubes“ with the cartoon style command. Helix tube mode is an alternative to the standard spiraling ribbons, and both modes are fully integrated with coil and β-strand cartoons. The structure at left is an AMPA-subtype glutamate receptor bound to the antiepileptic drug perampanel (PDB 5l1f). The receptor is tetrameric, and each chain is rainbow color-coded from blue at the N-terminus to red at the C-terminus. Four molecules of perampanel (pink) are bound near the bottom, between the transmembrane domain and the rest of the receptor. For image setup other than orientation, see the command file ampar.cxc.

See also: Presets menu

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Example Image

The Human Ribosome

The architecture of the human ribosome has been determined at near-atomic resolution by electron microscopy (Anger et al., Nature 497:80 (2013)). The structure, comprising 82 proteins and five RNA molecules, is shown with shadows cast from all directions to accentuate depth. In the background are schematic representations of contacts between the component molecules.

See the image setup script card.cxc using the 'Tis the Season color palette (credit to MrsP). See also the RBVI holiday card gallery.

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