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In-cell architecture of the mitochondrial respiratory chain. Waltz F, Righetto RD et al. Science. 2025 Mar 21;387(6740):1296-1301.

Structure and mechanism of vitamin-K-dependent γ-glutamyl carboxylase. Wang R, Chen B et al. Nature. 2025 Mar 20;639(8055):808–815.

Molecular basis of vitamin-K-driven γ-carboxylation at the membrane interface. Cao Q, Ammerman A et al. Nature. 2025 Mar 20;639(8055):816–824.

Evolutionary adaptations of doublet microtubules in trypanosomatid parasites. Doran MH, Niu Q et al. Science. 2025 Mar 14;387(6739):eadr5507.

Tunneling nanotube-like structures regulate distant cellular interactions during heart formation. Miao L, Lu Y et al. Science. 2025 Mar 14;387(6739):eadd3417.

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News

March 19, 2025

Wiley most-cited-paper medallion
UCSF ChimeraX: Tools for structure building and analysis is one of the 10 most cited papers published in Protein Science in 2023!

March 1, 2025

Bluesky logo Follow UCSF ChimeraX on BlueSky! @chimerax.ucsf.edu

December 25, 2024

The RBVI wishes you a safe and happy holiday season! See our 2024 card and the gallery of previous cards back to 1985.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325.

Bluesky logo ChimeraX on Bluesky: @chimerax.ucsf.edu

Feature Highlight

Morphing Movie

Morphing between atomic structures can be calculated wih the morph command and played back in an animation. This movie shows morphing between two conformations of the FGFR1 kinase domain:

  • inactive structure (PDB 3c4f, chain A)
  • activated structure (PDB 3gqi, chain A) with phosphorylated tyrosines and bound ATP analog
The tyrosine side chains and ATP analog are color-coded by element: light blue carbon, red oxygen, blue nitrogen, and orange phosphorus.

Morphing and other setup was done with the command file kmorph-prep.cxc, followed by interactively positioning the structure and saving the view with the command view name p1 (generally a session would also be saved at this point), then running kmorph-play.cxc to add 2D labels and record the movie.

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Example Image

The Human Ribosome

The architecture of the human ribosome has been determined at near-atomic resolution by electron microscopy (Anger et al., Nature 497:80 (2013)). The structure, comprising 82 proteins and five RNA molecules, is shown with shadows cast from all directions to accentuate depth. In the background are schematic representations of contacts between the component molecules.

See the image setup script card.cxc using the 'Tis the Season color palette (credit to MrsP). See also the RBVI holiday card gallery.

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