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In-cell architecture of the mitochondrial respiratory chain. Waltz F, Righetto RD et al. Science. 2025 Mar 21;387(6740):1296-1301.
Structure and mechanism of vitamin-K-dependent γ-glutamyl carboxylase. Wang R, Chen B et al. Nature. 2025 Mar 20;639(8055):808–815.
Molecular basis of vitamin-K-driven γ-carboxylation at the membrane interface. Cao Q, Ammerman A et al. Nature. 2025 Mar 20;639(8055):816–824.
Evolutionary adaptations of doublet microtubules in trypanosomatid parasites. Doran MH, Niu Q et al. Science. 2025 Mar 14;387(6739):eadr5507.
Tunneling nanotube-like structures regulate distant cellular interactions during heart formation. Miao L, Lu Y et al. Science. 2025 Mar 14;387(6739):eadd3417.
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UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.
ChimeraX is developed with support from National Institutes of Health R01-GM129325.
Feature Highlight
Morphing between atomic structures can be calculated wih the
morph command
and played back in an animation.
This movie shows morphing between two conformations of the FGFR1 kinase domain:
Morphing and other setup was done with the
command file kmorph-prep.cxc,
followed by interactively positioning the structure and saving the view
with the command
view name p1
(generally a
session would
also be saved at this point),
then running kmorph-play.cxc
to add 2D labels and record the movie.
Example Image
The architecture of the human ribosome has been determined at
near-atomic resolution by electron microscopy (Anger et al.,
Nature 497:80 (2013)).
The structure, comprising 82 proteins and five RNA molecules, is
shown with shadows cast from all directions to accentuate depth.
In the background are schematic representations of contacts
between the component molecules.
See the image setup script
card.cxc
using the
'Tis the Season color palette (credit to MrsP).
See also the RBVI
holiday card gallery.
Morphing Movie
The tyrosine side chains and ATP analog are color-coded by element:
light blue carbon, red oxygen, blue nitrogen, and orange phosphorus.
The Human Ribosome
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